Read e-book online Branching Processes in Biology PDF

By Marek Kimmel, David E. Axelrod

ISBN-10: 038795340X

ISBN-13: 9780387953403

This booklet presents a theoretical historical past of branching strategy and discusses their organic purposes. Branching techniques are a well-developed and robust set of instruments within the box of utilized chance. the diversity of functions thought of comprises molecular biology, mobile biology, human evolution, and drugs. The branching methods mentioned contain Galton-Watson, Markov, Bellman-Harris, Multitype, and normal approaches. As an reduction to figuring out particular examples, introductory chapters and glossaries are integrated that supply history fabric in arithmetic and in biology.

The e-book could be of curiosity to scientists who paintings in quantitative modeling of organic structures, quite probabilists, mathematical biologists, biostatisticians, cellphone biologists, molecular biologists, and bioinformaticians.

The authors are a mathematician and phone biologist who've collaborated for greater than a decade within the box of branching tactics in biology.

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Replication reinitiation is another possible mechanism that may contribute to gene amplification. It is visualized as the start of a new replication fork before the previous replication fork has completed moving through the DNA. This leads to the formation of branched DNA structures. 7. 9 Recombination Recombination is an exchange of pieces of DNA. Recombination can result in new combinations of genes and increases or decreases in the numbers of genes. Recombination occurs during the formation of germ cells for sexual reproduction (meiosis) and the division of nonsexual somatic body cells (mitosis).

The length (number of bases) of a tandemly repeated unit may be as short as 1 base or longer than 103 bases. The number of repeated units may be as small as 2 or larger than 102 . An increase in the number of tandemly repeated units is referred to as amplification, and a decrease as deamplification. The emergence of periodicities of tandemly repeated sequences in DNA by recombination slippage is simulated by a discrete stochastic dynamical system by Baggerly and Kimmel (1995). 7 or in Bat et al. (1997).

Differentiating the formula ft (s) f {f [· · · f (s) · · ·]} with t respect to s and substituting s 1, we obtain using the chain rule of differentiation: E[Zt ] ft (1−) [f (1−)]t mt . Therefore, in the expected value sense, the process grows geometrically if m > 1, stays constant if m 1, and decays geometrically if m < 1. These three cases are called supercritical, critical, and subcritical, respectively: m > 1, supercritical ⇒ m 1, m < 1, critical subcritical ⇒ ⇒ E[Zt ] ↑ ∞, E[Zt ] 1, E[Zt ] ↓ 0.

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Branching Processes in Biology by Marek Kimmel, David E. Axelrod


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