Download e-book for iPad: Bioinformatics for Beginners: Genes, Genomes, Molecular by Supratim Choudhuri

By Supratim Choudhuri

ISBN-10: 0124104711

ISBN-13: 9780124104716

Bioinformatics for novices: Genes, Genomes, Molecular Evolution, Databases and Analytical Tools offers a coherent and pleasant remedy of bioinformatics for any scholar or scientist inside of biology who has now not usually played bioinformatic analysis.

The e-book discusses the proper rules had to comprehend the theoretical underpinnings of bioinformatic research and demonstrates, with examples, precise research utilizing freely to be had web-based software program and publicly to be had databases. Eschewing non-essential details, the paintings specializes in ideas and hands-on research, additionally pointing to additional learn options.

  • Avoids non-essential insurance, but totally describes the sphere for beginners
  • Explains the molecular foundation of evolution to put bioinformatic research in organic context
  • Provides beneficial hyperlinks to the great source of publicly to be had bioinformatic databases and research tools
  • Contains over a hundred figures that relief in idea discovery and representation

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Extra info for Bioinformatics for Beginners: Genes, Genomes, Molecular Evolution, Databases and Analytical Tools

Example text

7 kb of at least one of the biochemical events measured by ENCODE. The analysis annotated 8801 small RNA and 9640 long noncoding RNA-coding loci. Greater than 62% of the genomic bases were found to be represented in . 200-nt-long RNA molecules. Most transcribed bases were found to be within annotated genes or in overlapping annotated gene boundaries; that is, in noncoding DNA. Also, 11,224 pseudogenes were annotated, of which 863 are transcribed and associated with active chromatin. An initial set of 399,124 regions with enhancer-like features and 70,292 regions with promoter-like features were annotated.

Hence, recombination involving self-splicing introns early in life’s evolution could not have played an important role in exon shuffling, and consequently in the evolution of ancient proteins. Exon shuffling most likely increased in parallel with the evolution and expansion of spliceosomal introns and the concomitant appearance of less compact genomes. Patthy analyzed the evolutionary distribution of some proteins that could be identified as modular proteins (containing specific functional modules) and seemingly evolved by intronic recombination.

Hawkins JD. Nucl Acids Res 1988;16:9893À908. Sterner DA, et al. Proc Natl Acad Sci USA 1996;93:15081À5. Choudhuri S, et al. Biochem Biophys Res Commun 2000;274:79À86. 37. 38. 39. 40. 41. 42. 43. 44. 45. Belshaw R, Bensasson D. Heredity 2006;96:208À13. Lambowitz AM, Zimmerly S. Annu Rev Genet 2004;38:1À35. Chorev M, Carmel L. Front Genet 2012;3:Article 55. Sauna ZE, Kimchi-Sarfaty C. Nat Rev Genet 2011;12:683À91. Edwalds-Gilbert G, et al. Nucl Acids Res 1997;25:2547À61. Choudhuri S. In: Choudhuri S, Carlson DB, editors.

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Bioinformatics for Beginners: Genes, Genomes, Molecular Evolution, Databases and Analytical Tools by Supratim Choudhuri


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