Read e-book online Bioinformatics for beginners : genes, genomes, molecular PDF

By Supratim Choudhuri

ISBN-10: 0124104711

ISBN-13: 9780124104716

Bioinformatics for Beginners offers a coherent and pleasant therapy of bioinformatics for any scholar or scientist inside biology who has no longer typically played bioinformatic research.

The e-book discusses proper ideas had to comprehend the theoretical underpinnings of bioinformatic research, and demonstrates with examples distinctive research utilizing freely on hand web-based software program and publicly to be had databases. Eschewing non-essential info, the paintings specializes in ideas and hands-on research and issues to many extra learn options.

  • Avoids non-essential assurance but absolutely describes the sector for newbies - in nearly two hundred pages of text
  • Explains the molecular foundation of evolution to put bioinformatic research in organic context
  • Provides necessary hyperlinks to the enormous source of publicly on hand bioinformatic databases and research tools
  • Over a hundred figures reduction in suggestion discovery and representation

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Additional info for Bioinformatics for beginners : genes, genomes, molecular evolution, databases and analytical tools

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Biochemistry 1991;30:6081À8. Grigoriev M, et al. Proc Natl Acad Sci USA 1993;90:3501À5. Chin JY, et al. Front Biosci 2007;12:4288À97. Kumar A. Eukaryot Cell 2009;8:1321À9. Kay RA, et al. Cancer Res 2005;65:10742À9. Hawkins JD. Nucl Acids Res 1988;16:9893À908. Sterner DA, et al. Proc Natl Acad Sci USA 1996;93:15081À5. Choudhuri S, et al. Biochem Biophys Res Commun 2000;274:79À86. 36. 37. 38. 39. 40. 41. 42. 43. 44. 45. Belshaw R, Bensasson D. Heredity 2006;96:208À13. Lambowitz AM, Zimmerly S. Annu Rev Genet 2004;38:1À35.

Increased numbers of triplet repeats are associated with a number of heritable genetic disorders in humans, such as Huntington’s disease (CAG repeats), myotonic dystrophy (CTG repeats), fragile-X syndrome (CGG repeats). A higher number of uninterrupted triplet repeats is usually correlated with an earlier onset and a greater severity of the disease. In contrast, interruption of the triplet repeats may reduce the predisposition of the carrier to the disease. For example, fragile-X syndrome in humans is associated with the expansion of the CGG triplet repeats in the FMR1 (fragile-X mental retardation 1) gene.

They also concluded that such a pattern was achieved since the early steps of animal evolution. 36 Although the presence of repetitive sequences in introns could facilitate intron recombination, insertion of repetitive sequences in self-splicing introns would not have been tolerated because self-splicing introns encode an essential function. In contrast, insertion of repetitive sequences would have been tolerated in spliceosomal introns because of the lack of such functional constraints. Hence, recombination involving self-splicing introns early in life’s evolution could not have played an important role in exon shuffling, and consequently in the evolution of ancient proteins.

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Bioinformatics for beginners : genes, genomes, molecular evolution, databases and analytical tools by Supratim Choudhuri


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