Download e-book for iPad: Basic Pharmacokinetics and Pharmacodynamics: An Integrated by Sara E. Rosenbaum

By Sara E. Rosenbaum

ISBN-10: 1119143152

ISBN-13: 9781119143154

Up-to-date with new chapters and themes, this ebook presents a entire description of all crucial subject matters in modern pharmacokinetics and pharmacodynamics. It additionally good points interactive computing device simulations for college students to test and discover PK/PD versions in action.

•    Presents the necessities of pharmacokinetics and pharmacodynamics in a transparent and innovative manner
•    Helps scholars larger have fun with vital ideas and achieve a better realizing of the mechanism of motion of gear through reinforcing functional purposes in either the publication and the pc modules
•    Features interactive computing device simulations, on hand on-line via a spouse site at: http://www.uri.edu/pharmacy/faculty/rosenbaum/basicmodels.html•    Adds new chapters on physiologically established pharmacokinetic versions, predicting drug-drug interactions,  and pharmacogenetics whereas additionally strengthening unique chapters to higher organize scholars for extra complex applications
•    Reviews of the first version: “This is a perfect textbook for these beginning out … and in addition to be used as a reference ebook …." (International Society for the research of Xenobiotics) and “I might suggest Rosenbaum’s ebook for pharmacology scholars since it is written from  a standpoint of drug motion . . . total, it is a well-written advent to PK/PD …. “  (British Toxicology Society e-newsletter)

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Extra resources for Basic Pharmacokinetics and Pharmacodynamics: An Integrated Textbook and Computer Simulations

Example text

A partial agonist will block the effect of a full agonist. In the presence of high concentrations of a partial agonist, the action of a full agonist can be reduced to the maximum response elicited by the partial agonist. Clinically, partial agonists are used to act as buffers to avoid full stimulation of a system. Examples of partial agonists include several β-blockers, including pindolol, and the opioid buprenorphine. The latter is a partial agonist on the μ-opioid receptors and is considered a safer alternative to morphine because it does not produce as much respiratory depression (see Chapter 19).

At this point, the drug has been absorbed. The rate and extent of absorption of a drug are very important determinants of the early plasma concentrations of a drug. Rapid rates of absorption will promote high early plasma concentrations. Once the heart pumps the drug around the body, the drug is given the opportunity to distribute to all the tissues, including the biophase or site of action. A drug’s distribution pattern, particularly the rate and extent to which it distributes to the tissues, is also an important determinant of the early plasma concentrations.

Courtesy of Linnea E. Anderson. 72 Source: Reference [1]. size of the drug molecule. A drug’s lipophilicity is probably the most important determinant of permeability. A drug’s lipophilicity, or fat-loving nature, is traditionally assessed by measuring its distribution between the immiscible phases of n-octanol and water. 4) Because of the very wide range of P values among therapeutic drugs, P values are expressed most conveniently on a log scale. 1 provides the log P values of some therapeutic drugs.

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Basic Pharmacokinetics and Pharmacodynamics: An Integrated Textbook and Computer Simulations by Sara E. Rosenbaum


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