Get Antiepileptic Drug Interactions: A Clinical Guide PDF

By Philip N Patsalos

ISBN-10: 3319329081

ISBN-13: 9783319329086

ISBN-10: 331932909X

ISBN-13: 9783319329093

This up-to-date 3rd version of a profitable e-book is an outline of either pharmacokinetic and pharmacodynamic antiepileptic drug (AED) interactions, together with info of the value and mechanism of interactions, and likewise of drug combos that aren't linked to interactions and consequently should be coprescribed with out undue situation. offered in alphabetical order and through drug classification, drug interactions that ensue among AEDs and in addition among AEDs and non-AEDs are defined in 3 sections: Drug interactions among AEDs; Drug interactions among AEDs and non-AED medicines: Interactions affecting AEDs; Drug interactions among AEDs and non-AED medicines: Interactions suffering from AEDs.

Antiepileptic Drug Interactions: A medical consultant, third Edition with its transparent, concise and unambiguous content material will

allow physicians and allied overall healthiness pros to make extra rational offerings while AED polytherapy regimens are indicated. there's consistently a decision and warding off hugely interacting medications and selecting drug mixtures which are minimally interacting or don't engage could be the objective in treating sufferers with epilepsy. This booklet offers all of the invaluable info as a way to let this target to be accomplished and, if helpful, to help powerful administration of AED interactions.

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Extra info for Antiepileptic Drug Interactions: A Clinical Guide

Sample text

2000;342:314–9. 3. Patsalos PN, Froscher W, Pisani F, van Rijn CM. The importance of drug interactions in epilepsy therapy. Epilepsia. 2002;43:365–85. 4. Patsalos PN, Perucca E. Clinically important drug interactions in epilepsy: general features and interactions between antiepileptic drugs. Lancet Neurol. 2003;2:347–56. 5. Johannessen Landmark C, Patsalos PN. Drug interactions involving the new second- and thirdgeneration antiepileptic drugs. Exp Rev Neurother. 2010;10:119–40. 6. Patsalos PN, Perucca E.

Introduction xxix in profound sedation that cannot be explained solely by a pharmacokinetic interaction. Lamotrigine and valproic acid in combination may produce disabling tremor [10]. Examples of potential favorable drug combinations include valproic acid and ethosuximide in the management of refractory absence seizures [11]; valproic acid and lamotrigine in the management of partial and generalized seizures [12]; and carbamazepine and valproic acid in the management of partial seizures [13]. Pharmacodynamic interactions between AEDs and non-AEDs can also result in increased toxicity.

CNS Drugs. 2008;22:27–47. 9. Patsalos PN, Bourgeois BFD. The epilepsy prescriber’s guide to antiepileptic drugs. Cambridge: Cambridge University Press; 2nd Ed, 2014. 10. Reutens DC, Duncan JS, Patsalos PN. Disabling tremor after lamotrigine with sodium valproate. Lancet. 1993;342:185–6. 11. Rowan AJ, Meijer JW, de Beer-Pawlikowski N, van der Geest P, Meinardi H. Valproateethosuximide combination therapy for refractory seizures. Arch Neurol. 1983;40:797–802. 12. Pisani F, Oteri G, Russo MF, Di Perri R, Perucca E, Richens A.

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Antiepileptic Drug Interactions: A Clinical Guide by Philip N Patsalos


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