Download e-book for iPad: Advances in veterinary science and comparative medicine. by James L Bittle; Frederick A Murphy

By James L Bittle; Frederick A Murphy

ISBN-10: 012039233X

ISBN-13: 9780120392339

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Extra resources for Advances in veterinary science and comparative medicine. Vol. 33, Vaccine biotechnology

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Laidlaw and Dunkin (1926, 1928a,b) prepared a vaccine by treating virus derived from spleens of infected dogs with formalin. Initial administration of this vaccine, followed 2 weeks later with a small dose of virulent virus, usually produced only a mild disease with solid immunity. This approach was replaced with inactivated virus vaccines, given in multiple doses, which served as the main means of controlling the disease from 1930 to 1950. Green (1945) serially passaged canine distemper virus in ferrets and produced the first attenuated live-virus vaccine; however, this vaccine caused disease in some dogs.

Botulinum), enterotoxemia, and dysentery (C. perfringens). The Clostridia are widely distributed in soil and water and a r e common inhabitants of the intestinal tracts of animals and humans. Additionally, the bacteria can often be isolated from infected wounds. Vaccination is not routinely practiced against all clostridial organisms, notably C. botulinum. The toxins of C. botulinum, which exert their effects upon the nervous system (Schantz and Sugiyama, 1974), are as potent as those of C. tetani.

Animals immunized with cell-free culture fluids develop agglutinins to the whole bacteria (White and Verway, 1970). Such vaccines are highly effective in controlling swine erysipelas. VACCINES PRODUCED BY CONVENTIONAL MEANS D. 39 Clostridium The pathogenic Clostridia invade both m a n and m a n y animal species of veterinary interest, in which they cause such diseases as tetanus (C. tetani), gas gangrene (C. perfringens, C. septicum, C. oedematous), botulism (C. botulinum), enterotoxemia, and dysentery (C.

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Advances in veterinary science and comparative medicine. Vol. 33, Vaccine biotechnology by James L Bittle; Frederick A Murphy


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